For a while, lots of people were playing online with software like maptool. However, there are at least five different editions, not including all of the spin-offs like Pathfinder. It kind of makes me wonder how they all agree on a rule set to use. 🙂
Back in the day, I played D&D, AD&D, GURPS, Champions, Traveler, Gamma World, Fantasy Trip, Call of Cthulhu, etc. But I think Tunnels & Trolls was my favorite.